发给老马备查:
& y# k! b* G: I" T1 i2 d滴水察海(69304838) 15:23:23
+ T0 l& i' a+ {老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
0 ?4 f1 L# D5 N吉非替尼和S-1连用的依据
5 y/ n! H0 H+ N* Y" G% \8 DGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.+ E% R) ~1 v7 d# j7 e
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达% j2 v$ ~2 Z" H3 ~* P! B( d
这样是不是推理出,耐药后,可以用S-1和培美了?8 S5 {0 N, N$ E1 g6 l+ h9 i* W. M1 f
结论:: ^- h2 _/ D* ?; [
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |