看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。- Y, K5 K3 `* W+ q+ p- S
0 `1 ` p$ O+ p
2 K7 |6 b* I2 i2 I
Currently available feasibility data for possible combination strategies.
1 @, b2 `4 K4 P) T————————————————————————————————( K% C" T! t0 l0 J
Combination Feasibility according to preliminary data 2 D% M0 O( a9 U( ?
——————————————————————————————————' j$ y" X! ?# }) }& w; W
Bevacizumab + sorafenib Yes, reduced dose ' s5 h# h7 l* ], |+ S6 K! E
Bevacizumab + sunitinib† No
2 V; Z' j( N# }$ v. N H; H, {, xBevacizumab + temsirolimus Yes
! k P" i2 g! k- H% D2 T; Z# TBevacizumab + everolimus Yes . g! `0 s* g# P S
Sorafenib + sunitinib ? ' {, Y7 G+ v+ r1 O0 D
Sorafenib + temsirolimus Yes, reduced dose
Q/ t+ \$ ^9 y4 T' K. @/ N6 cSorafenib + everolimus Yes, reduced dose
# E, {5 |7 r: j/ Z5 v. TSunitinib + temsirolimus† No % u8 H$ ^4 g5 L/ p8 R* x1 s
Sunitinib + everolimus ?
8 k, c) v2 Z: L/ yTemsirolimus + everolimus ?
. t. @; F j5 V————————————————————* { s: c$ h$ S$ n9 I3 q
†Led to US FDA warning.! Z0 e0 E+ Q- u5 A( }, Z+ S
?: As yet unattempted combination.' e. j' x; F. s8 `% p/ x2 f% K6 \# `
|